The effect of nerve stimulation on the synthesis and metabolism of norepinephrine in the isolated guinea-pig hypogastric nerve-vas deferens preparation.
نویسندگان
چکیده
Studies on the Mechanism of the Hypertensive Effect of Prostaglandin F . D. W. DUCHARME, J. R. WEEKS AND R. G. MONTGOMERY 1 Venoconstrictive Action of Bradykinin. RICHARD P. BOBBIN AND PAUL S. GUTH... 11 Antiarrhythmic Activity of Some Isoquinoline Derivatives Determined by a Rapid Screening Procedure in the Mouse. JAMES W. LAWSON 22 The Effects of Reserpine on Vasopressin-Cholesterol-Induced Atheromatous Lesions. PEGGY J. WHITTINGTON-COLEMAN, OLIVER CARRIER, JR. AND BER R. CLOWER.. 32 Application of Steady-State Kinetics to the Study of Catecholamine Turnover after Monoamine Oxidase Inhibition or Reserpine Administration. N. H. NEFF AND
منابع مشابه
Electrical response of guinea-pig seminal vesicle to hypogastric nerve stimulation in vivo and effect of reserpine.
中西 弘則 ・武 田 寛 The isolated vas deferens-hypogastric nerve preparation of the guinea-pig has been considered to represent a sympathetic adrenergic junction from the results that the motor response of the tissue to hypogastric nerve stimulation is enhanced by the addition of noradrenaline and is abolished by the previous reserpinization of the animal (1). Recently, Burnstock and Holman (2) attende...
متن کاملPresence of prejunctional D2-dopaminoceptors and α2-adrenoceptors on the cholinergic nerve of the common bile duct of guinea pig
On most adrenergic and cholinergic nerve terminals, prejunctional α-adrenoceptors belonging to the α2-subtype have been identified. Activation of these receptors will decrease the release of norepinephrine. It has been reported that several isolated tissue preparations contain prejunctional dopamine receptors, the stimulation of which inhibits neurotransmission. It has remained uncertain whethe...
متن کاملA comparative study on the effects of new opioid compounds and morphine on the contractility of guinea pig ileum and mouse vas deferens
Considering the clinical significance of opioids, especially their application for the treatment of severe painful conditions including cancer pain and the requirement for the synthesis of more specific drugs with lower side effects, this study was conducted to perform a preliminary investigation on six newly developed opioid drugs. Our aim was to introduce drugs that act selectively on the opi...
متن کاملAn inhibitory effect of ethanol on adrenergic neuromuscular transmission in the guinea-pig vas deferens.
Effects of ethanol on adrenergic neuromuscular transmission were investigated in the isolated vas deferens of the guinea-pig. The contractile responses to adrenergic nerve stimulation were depressed by ethanol in a concentration-dependent, reversible manner at a concentration range between 25 and 500 mM. Ethanol also depressed the contractions induced by exogenous noradrenaline. The resting mem...
متن کاملThe presynaptic activity of huwentoxin-I, a neurotoxin from the venom of the chinese bird spider Selenocosmia huwena.
Three different types of isolated nerve-synapse preparations, guinea pig ileum, rat vas deferens and toad heart, were used to investigate the physiological activity of Huwentoxin-I, a neurotoxin from the venom of the spider Selenocosmia huwena. The twitch response of isolated guinea pig ileum induced by electrical stimulus can be inhibited by HWTX-I. After blockage, contraction of the ileum can...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of pharmacology and experimental therapeutics
دوره 160 1 شماره
صفحات -
تاریخ انتشار 1968